Merkel cell polyomavirus and non-small cell lung cancer
نویسندگان
چکیده
منابع مشابه
Merkel cell polyomavirus and extrapulmonary small cell carcinoma
The Merkel cell polyomavirus (MCV) is involved in the development of up to 100% of Merkel cell cancer (MCC) cases. Early studies have reported that the virus was infrequently detected in other small cell or neuroendocrine lung carcinomas, which share histological features with MCC. The present study investigated the presence of MCV in cases of extrapulmonary small cell carcinoma (ESCC), which a...
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These findings contradict existing evidence showing MCV sT protein expression in MCVMCC cancer tissues (Shuda et al., 2011) and cell lines (see Figure. 2, Houben et al., 2010) (Guastafierro et al., 2013). To investigate this discrepancy, we tried replicating Angermeyer et al's results using the same antibodies to detect MCV sT (CM8E6 (Kwunet al., 2009), CM5E1 (Shuda et al., 2011) and 2T2 ((Wang...
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Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine skin cancer of elderly patients. Generally, it originates from Merkel cells of the basal layer of the epidermis characterized by typical neuroendocrine granules (neuron-specific enolase; NSE+) and keratin filament (cytokeratin-20; CK20). Its incidence has been increasing in the last two decades, likely because of improved ability t...
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of the fi rst diagnosed case (in Spain) in a human with aseptic meningitis.lence of West Nile virus neutralizing an-tibodies in colonial aquatic birds in southern Spain. and performance testing of quantitative real time PCR assays for infl uenza A and B viral load measurement. Detection and differentiation of pathoge-nicity of avian paramyxovirus serotype 1 from fi eld cases using one-step reve...
متن کاملLarge T and small T antigens of Merkel cell polyomavirus.
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural component of skin flora, MCV becomes tumorigenic only after integration into the host DNA together with specific mutations to the viral genome. Research on MCV large T (LT) and small T (sT) antigens, the only viral products expressed in MCC, shows that th...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2013
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2013.195